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SDZ 220-040

Name: SDZ 220-040
Brand: TargetMol
SKU: T23344
Price: 62 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23344Cas No. 174575-40-7

Alias SDZ-220-040

SDZ 220-040 is a selective mammalian NMDA receptor antagonist that induces a partially gravity-free mode of root growth.

SDZ 220-040

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Purity: 98.13%

Catalog No. T23344Alias SDZ-220-040Cas No. 174575-40-7

SDZ 220-040 is a selective mammalian NMDA receptor antagonist that induces a partially gravity-free mode of root growth.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$62	In Stock	In Stock
5 mg	$145	In Stock	In Stock
10 mg	$213	In Stock	In Stock
25 mg	$463	In Stock	In Stock
50 mg	$896	In Stock	In Stock
100 mg	$1,180	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.13%

ee:100%

Appearance:Solid

Color:White

Resource Download

COA CSFC HNMR LCMS PNMR

Product Introduction

SDZ 220-040 AI Summary

SDZ 220-040 exhibits a wide range of bioactivities across different assays and targets. It inhibits beta-lactamase AmpC with an IC50 of 160,000 nM, which increases to 220,000 nM in the presence of 0.1% Triton X-100. It also inhibits chymotrypsin with an IC50 of 270,000 nM, and this value rises to 400,000 nM in the presence of 0.1% Triton X-100. The compound has a moderate inhibitory effect on cruzain, with an IC50 of 77,000 nM, increased to 158,000 nM in the presence of 0.01% Triton X-100. It does not show significant inhibition of malate dehydrogenase (IC50 > 600,000 nM). In addition, SDZ 220-040 demonstrates inhibitory activity against Menin-MLL interaction, HSD17B4, cytochrome P450 enzymes (2C19, 2C9), aldehyde dehydrogenase 1 (ALDH1A1), 15-hLO, ERK signaling, HPGD, GCN5L2, polymerase kappa, and vitamin D receptor (VDR), as well as USP1/UAF1. It also exhibits agonistic activity towards the Thyroid Stimulating Hormone Receptor and modulates lipid storage. In antiviral assays, SDZ 220-040 shows activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity of Caco-2 cells with an inhibition rate of 5.78% at 10 µM after 48 hours and a 3CL-Pro protease inhibition of -13.01% at 20 µM. When tested against VERO-6 cells, it exhibits an inhibition rate of 0.16% at 10 µM after 48 hours. Additionally, it shows a modest inhibitory effect against human HDAC6 in an enzymatic assay, with a 4.67% inhibition rate using a commercial peptide substrate, but a decreased rate of -1.76% with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	SDZ 220-040 is a selective mammalian NMDA receptor antagonist that induces a partially gravity-free mode of root growth.
Synonyms	SDZ-220-040

Chemical Properties

Molecular Weight	420.18
Formula	C₁₆H₁₆Cl₂NO₆P
Cas No.	174575-40-7
Smiles	ClC1=C(C2=CC(C[C@@H](C(O)=O)N)=C(O)C(CP(=O)(O)O)=C2)C=CC(Cl)=C1
Relative Density.	1.612 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (119 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3799 mL	11.8997 mL	23.7993 mL	118.9966 mL
5 mM	0.4760 mL	2.3799 mL	4.7599 mL	23.7993 mL
10 mM	0.2380 mL	1.1900 mL	2.3799 mL	11.8997 mL
20 mM	0.1190 mL	0.5950 mL	1.1900 mL	5.9498 mL
50 mM	0.0476 mL	0.2380 mL	0.4760 mL	2.3799 mL
100 mM	0.0238 mL	0.1190 mL	0.2380 mL	1.1900 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc